Experts Reveal the Secret Powers of Grapefruit Juice. Exploring mechanisms of this interaction and potential toxicity for certain drugs. Interactions between grapefruit juice and cardiovascular drugs. Effect of grapefruit juice on carbamazepine bioavailability in patients with epilepsy. ↑ Garg SK, Kumar N, Bhargava VK, Prabhakar SK.↑ 4.0 4.1 Bailey DG, Malcolm J, Arnold O, Spence JD.Inactivation of cytochrome P450 3A4 by bergamottin, a component of grapefruit juice. ↑ He K Iyer KR Hayes RN Sinz MW Woolf TF Hollenberg PF.Nutrient content and nutrition labeling of several processed Florida citrus juice products. ↑ The World's Healthiest Foods Grapefruit.It is believed that the fruit boosts the levels of estrogen, which in turn increases the risk of developing the disease. The Study found that in the test subjects, 50,000 post-menopausal women, eating just a quarter of a grapefruit daily raised the risk by up to 50%. Breast cancer linkĪ recent study published in the July 2007 edition of the British Journal of Cancer reported that eating grapefruit every day could raise the risk of developing breast cancer by almost a third. Juice of limes and Seville oranges can also inhibit drug metabolism, however, as can apple juice with some drugs. It is sometimes recommended as a substitute. Orange juice does not contain naringin in as high a concentration, instead containing hesperetin. Other flavonoids exist in grapefruit juice in lower concentrations as well. The flavonoid existing in highest concentration in grapefruit juice is naringin, which in humans is metabolized to naringenin. Examples of such known CYP3A4 inhibitors include cisapride (Propulsid), erythromycin, itraconazole (Sporanox), ketoconazole (Nizoral), and mibefradil (Posicor). ĭrugs that may be affected include midazolam, ciclosporin, lovastatin, simvastatin, pravastatin, felodipine, sildenafil (Viagra) and caffeine, as well as a number of antihistamines including astemizole and terfenadine.Īn easy way to tell if a medication may be affected by grapefruit juice is by researching whether another known CYP3A4 inhibitor drug is already contraindicated with the drug in question. Recently some researchers have shown that furanocoumarins rather than flavinoids may be the ingredients causing the various drug interactions. However, the effect became well-publicized after being responsible for a number of deaths due to overdosing on medication. The effect of grapefruit juice with regard to drug absorption was originally discovered in 1989. In some cases, this can lead to a fatal interaction with drugs like Astemizole. Grapefruit juice, and grapefruit in general, is a potent inhibitor of the Cytochrome_P450 enzyme CYP3A4, which can impact the metabolism of a variety of drugs, increasing their bioavailability.

It's not as efficient as a big juicer, but it does the trick.Ģ) To a highball glass filled with ice, add the grapefruit juice, gin or vodka, St.Germain and stir.Ĥ) Garish with some mint.Main article: List of drugs affected by grapefruit I use a little hand held juicer - sort of like this: We use Pellegrino just because we have it on hand.ġ) Juice the grapefruit. Seltzer or your favorite sparkling water.The juice of one fresh ruby red grapefruit per person.2 shots of your favorite spirit - have just done gin or vodka, think tequila would be yummy! Guess I'll be trying that tonight.If you're really in a time crunch, you can sub out the fresh grapefruit for bottled, but if you have the extra three minutes, the fresh juice really does make all of the difference! You can even make a big batch in advance for when company comes over! (Or just save it all for yourself! teehee!) It's refreshing and since it uses actual fresh juice, it's packed with tons of vitamins so it must have some health benefits, right? Bueller? What I love about this cocktail is it feels fancy enough for a weekend but it's also quick to whip up on a weekday. I have been loving this grapefruit and elderflower cocktail with either gin or vodka and have been making it quiiite often. 2.5, cloudy beer is made with real grapefruit juice mixed with beer. Cocktail Recipe du Jour: Grapefruit/Elderflower Cooler Ruby red grapefruit, bread-like malts, slight spices, tropical fruits, and bright, aromatic pine are present on the nose.

Ruby red grapefruit juice shooters